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Because conventional formulations are limited by poor bioavailability, gastrointestinal intolerance, and suboptimal tissue targeting, innovative drug delivery systems, such as nanoparticles, pH-responsive hydrogels, and microneedles, are being developed to enhance therapeutic efficacy, reduce adverse effects, and improve patient adherence (Sulong et al., 2025)

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A woman who is GSTM1 null faces depleted glutathione conjugation capacity for both estrogen quinones and environmentally-derived reactive metabolites simultaneously a compounded oxidative burden that blood panels cannot quantify but genetics surfaces as a baseline predisposition